Instructions for use, abstract, side effects. Panadol syrup for children, instructions for use

And citric acid.

Rectal suppositories,Panadol suppositories for children— each suppository contains 125 mg of paracetamol. Solid fats act as auxiliary components.

Release form

Suspension , Panadol syrup

It has a pink color and a strawberry smell. The syrup is viscous in consistency and contains crystals. Packaged in 100 or 300 ml bottles. In addition to the bottle, the cardboard pack contains instructions and a special measuring syringe.

Candles

The suppositories have a homogeneous consistency of white color, cone-shaped, have a greasy sheen, do not contain foreign impurities and various physical defects. Candles are packaged in strips of 5 or 10 pieces.

pharmachologic effect

Antipyretic-analgesic . The mechanism of action is based on blocking the enzyme cyclooxygenase in the central part of the nervous system. Thanks to the ability to influence the centers of thermoregulation and pain, it is achieved antipyretic And analgesic effect . Panadol for children does not have an anti-inflammatory effect. The active substance does not affect synthesis processes in peripherally located tissues, does not affect water-salt and does not irritate the mucous membranes of the digestive tract.

Pharmacodynamics and pharmacokinetics

Suction, distribution

Paracetamol has high absorption. The active substance is almost completely and quickly absorbed from the lumen of the digestive tract. After 30-60 minutes, the maximum concentration of the active substance is recorded in the blood. Paracetamol is only 15% bound to plasma proteins. The active component is distributed evenly in body fluids.

Metabolism

As a result of metabolism in the hepatic system, several active metabolites are formed. The main metabolite in newborns and children 3-10 years old is paracetamol sulfate , and in children over 12 years of age the main metabolite is conjugated glucuronide .

About 17% of the drug undergoes hydroxylation with the formation of active metabolites. The main metabolic products are conjugated with the participation of glutathione, with a deficiency of which Panadol metabolites begin to block the enzyme systems of hepatocyte liver cells, causing.

Removal

During the first day, 90-100% of the therapeutic dose taken is excreted in the urine. The half-life is 2-3 hours. Metabolites are eliminated after undergoing the conjugation process in the hepatic system. About 3% of the drug is excreted unchanged.

Indications for use

Panadol for children is prescribed to children from 3 months of age to 12 years of age:

pain during teething;
sore throat;
ear pain with;
decline elevated temperature body with infectious lesions, colds, , , , , and etc.

Children aged 2-3 months are allowed a single dose of antipyretic medication after vaccination.

Contraindications

neonatal period;
severe pathology of the renal system or liver;
individual hypersensitivity.

Relative contraindications:

severe pathology of the blood system ( leukopenia , anemia , thrombocytopenia );
genetically determined lack of the enzyme glucose-6-phosphate dehydrogenase;
pathology of the renal system;
Gilbert's syndrome and other diseases of the liver system.

The simultaneous use of other medications, one of the components of which is paracetamol, is prohibited.

Side effects

epigastric pain;
vomit;
skin rashes;
nausea;
thrombocytopenia ;
itchy skin;
leukopenia ;
anemia .

Taking the dosages recommended by the manufacturer allows you to avoid negative symptoms. If other adverse reactions not described in the instructions are registered, immediate cessation of therapy and seeking medical help from an appropriate specialist is required.

Children's Panadol, Instructions for use (Method and dosage)

Children's Panadol syrup, instructions for use

Shake the bottle thoroughly before use. Correct and rational dosing is ensured by a special measuring syringe included in the package.

Instructions for the suspension for children:

From 3 months: 3-4 times a day, 15 mg/kg body weight. No more than 60 mg/kg can be prescribed per day. It is acceptable to take syrup for children every 4-6 hours, but not more than 4 times a day (at the recommended dose of 15 mg/kg). The dosage is selected individually, taking into account concomitant pathology, drug tolerance, and the child’s age.

In order to reduce body temperature, Panadol for children can be taken for no longer than 3 days; for pain relief - 5 days. If there is no expected effect, a pediatrician's consultation is required.

Instructions for Panadol suppositories for children

Suppositories are intended for rectal administration (dosage of paracetamol 125 mg). Children's suppositories are administered every 4-6 hours, 1 suppository (for children from 3 months to 3 years). Candles can be used no more than 3 times a day.

Overdose

Acute poisoning is manifested by vomiting, increased epigastric pain, nausea, and pale skin. 1-2 days after poisoning, the first signs of toxic damage to the hepatic system appear (increased levels of ALT and AST, pain in the liver area). In extremely severe cases, liver failure and coma develop.

With chronic overdose, toxic damage to the kidneys and liver gradually develops:

interstitial nephritis
Analogs

Level 4 ATX code matches:
- Sanidol ;
- Passer ;
- Pyrimol ;
- Pacimol ;
- Perfalgin .

Suction and distribution

Absorption is high. Paracetamol is quickly and almost completely absorbed from the gastrointestinal tract. Cmax in plasma is achieved within 30-60 minutes.

Plasma protein binding is about 15%. The distribution of paracetamol in body fluids is relatively even.

Metabolism

Metabolized primarily in the liver with the formation of several metabolites. In newborns in the first two days of life and in children 3-10 years of age, the main metabolite of paracetamol is paracetamol sulfate; in children 12 years of age and older, it is conjugated glucuronide.

Part of the drug (approximately 17%) undergoes hydroxylation to form active metabolites that are conjugated with glutathione. With a lack of glutathione, these metabolites of paracetamol can block the enzyme systems of hepatocytes and cause their necrosis.

Removal

T1/2 when taking a therapeutic dose ranges from 2-3 hours. When taking therapeutic doses, 90-100% of the dose taken is excreted in the urine within one day. The main amount of the drug is released after conjugation in the liver. No more than 3% of the received dose of paracetamol is excreted unchanged.

When the temperature rises above 38 degrees, it is recommended to reduce it with medications using Panadol. This medicine reduces fever and relieves pain symptoms. The main component of the medicine: paracetamol, approved by WHO to relieve fever and eliminate pain.

Parents have no reason to worry when their children’s temperature rises sharply due to illness. High temperature causes the body to produce, which protects the body from viruses and bacteria, so the child’s body learns to cope with diseases.

Of course, there is no need to make a child suffer if heat causes inconvenience. Whether to give an antipyretic or not is determined by how the child feels. If he is weak, drowsy, capricious, does not feel well, feels pain, or signs of dehydration appear, it is better to bring down the temperature with Panadol or its analogues.

The main function of the product: lowering the temperature for colds and flu. With the help of Panadol, parents relieve fever when their children are sick with chickenpox, whooping cough, measles, rubella, scarlet fever, mumps and other infections. It is used in cases of otitis and tonsillitis. Panadol is used for teething children.

The active component of the drug, paracetamol, is used to relieve fever after vaccinations. An important advantage of the medicine: the ability to use it for children from the third month of life. Paracetamol has no effect on water-salt metabolism child's body and the condition of the mucous membrane of the stomach and intestines.

Instructions for use and dosage

In pharmacy kiosks, Panadol is found in several forms. These include tablets, powder for preparing a solution, suppositories, syrup (suspension), and capsules. The form of medication taken by the patient depends entirely on the age, condition of the patient and sensitivity to the drug.

For young children, the medicine is available in several forms: suspension (syrup), rectal suppositories, tablets.

The suspension is used for oral use; it is bottled in 100 mg bottles. The syrup has a pleasant strawberry taste and aroma. The medicine box contains a measuring syringe and a dosage table, from which it is easy to understand how much the dosage will be depending on age and weight. After the child takes the antipyretic medicine (suspension), it acts within 20 minutes and remains effective for up to 3–4 hours.

The syrup is taken every 4–6 hours, depending on the severity of the disease. The syrup is given from the third month of life, which is convenient for the treatment of colds and infectious diseases in infants.

The course without consulting a doctor is no more than 3 days. If the dose of medication is exceeded, it is recommended to consult a doctor.

Instructions for using Panadol are as follows:
For children aged 2–3 months, syrup can be given only on an individual prescription from a pediatrician;
For children 6–8 kg aged from three to six months, only 4 mg can be given once, the maximum daily dose for them will be 16 mg;
For children aged from one to two years, a single dose of medication is 7 mg, and the daily dose is 28 mg.

When treating fever and pain with suppositories, the recommended daily dose is no more than 4 pieces. Place Panadol suppositories 3-4 times every four to six hours. The effect of one candle reaches six hours. Suppositories are used when the child reaches six months of age. The therapeutic effect of the Panadol suppository begins 1–2 hours after rectal administration. The suppositories are administered rectally.

The medicine, produced in the form of tablets, is blisters designed for 6 and 12 tablets. The tablets themselves white with embossing. Children are recommended to take tablets only from 6 years of age. The instructions say the maximum recommended dose per day is 4 tablets:

A child from 6 to 9 years old is recommended to take half a tablet (250 mg) 3-4 times a day, with an interval of at least 4 hours. They are allowed to take a maximum of 2 tablets per day;
A child from 9 to 12 years old is recommended to take one tablet 3-4 times a day; tablets should not be given more often than once every 4 hours.

Do not take the medicine for more than 5 days as a pain reliever and no more than 3 days as an antipyretic. Exceeding the dosage or increasing the course of treatment is permitted only by a doctor; you cannot increase the dosage of the medicine yourself.

When treated with metoclopramide and domperidone, the rate of absorption of the active substance Panadol into the blood increases. Panadol enhances the effect of warfarin, possibly increasing the risk of bleeding. The use of barbiturates reduces the antipyretic effect of the active substance of the drug, possibly increasing the toxic effect of the liver. The antipyretic drug Panadol reduces the effect of diuretics.

Contraindications and side effects

Panadol is not recommended for use with other drugs containing paracetamol to avoid overdose;
The product should not be taken by children with kidney and liver diseases;
If the patient is given a concurrent course of rifampicin or treatment with anticonvulsants, there is a risk of toxicological liver damage;
The medicine is recommended to be used with caution in children under 3 months;
Panadol should not be used for children with fructose intolerance;
The medicine is not given to premature infants who are underweight;
Sometimes the drug causes a laxative effect.

Among the adverse reactions to the drug, doctors record allergic reactions in the form of rashes on the skin. They stop when the drug is discontinued within 24–48 hours. Side effects become fully apparent when the drug is overdosed. On the first day, pale skin, abdominal pain, nausea and vomiting occur. On the first or second day after an overdose, toxic damage to the kidneys and liver occurs, up to the development of liver failure, the consequences of which can be encephalopathy, coma, and death. Cardiac arrhythmia and pancreatitis may occur.

In case of an overdose of the drug, immediate medical attention is necessary, even if the symptoms have not yet manifested themselves.

At home, the stomach is washed, prescribed Activated carbon. After exceeding the dosage, N-acetylcysteine or methionine is prescribed for 2 days. If necessary, the doctor prescribes an alpha-blocker as maintenance therapy. After an overdose, a period of increased sensitivity to iodine-containing drugs is possible.

Analogs

This medicine has many analogues that have antipyretic and analgesic effects. Analogue medications are developed on the basis of various substances (paracetamol, ibuprofen, etc.). For example, analogues of Panadol are drugs containing paracetamol:

. The drug is available in the form of syrup and tablets. Tablets are packed in 10, 20 pieces. Manufacturer: Pharmstandard. Country of origin: Russia;
Calpol. Available in the form of a suspension. Bottle with a capacity of 100 ml. Country of origin: Germany;
. The medicine is available in the form of suppositories, capsules and syrup, and effervescent tablets. Country of origin: France;
. Release form: candles. The medicine was manufactured in Russia;
Perfalgan. Injections produced by French pharmacists;
Strimol. Available in tablet form. Country of origin: Netherlands.

One of the analogue drugs of Panadol is considered to be the main substance of which is ibuprofen. Nurofen is available in the form of effervescent tablets, suppositories, and syrup. Nurofen is available in orange or strawberry flavors. The bottle of Nurofen syrup has protection against small patients so that the child does not open and drink the sweet syrup. It is also equipped with a plastic measuring syringe, which will help avoid overdose. The drug effectively copes with the reduction of fever during colds and infectious diseases, relieves pain of various origins.

Drug price

The price of Panadol depends on the trade markup of pharmacies, the region of the country in which the medicine was purchased and on the form of release. For example, the price of a medicine produced in the form of rectal suppositories varies from 66 rubles to 69 rubles. The syrup form of the medicine costs from 93 to 99 rubles, depending on the pharmacy chain, trade markup, and drug supplier. On average, the price of medicine in tablet form varies from 29 to 33 rubles. It is worth remembering that the delivery of medicine from an online pharmacy to the client is prohibited according to federal legislation on the circulation of medicines.

Name: Panadol Baby

pharmachologic effect
Panadol Baby – medicinal product for use in pediatrics, with antipyretic and analgesic effects. The drug contains the active substance - paracetamol - a drug from the group of non-selective non-steroidal anti-inflammatory drugs. The mechanism of action of the drug is based on its ability to inhibit the enzyme cyclooxygenase, as a result of which the synthesis of prostaglandins is inhibited. Reducing the amount of prostaglandins in the central nervous system helps eliminate pain, and the direct effect of the drug on the thermoregulation center helps reduce elevated body temperature. The anti-inflammatory effect of the drug is insignificant, since paracetamol is inactivated by cellular peroxidases.
After oral administration, the drug is well absorbed from the digestive tract, the maximum plasma concentration of paracetamol is observed 15-60 minutes after oral administration. Metabolized in the liver, excreted in the urine in the form of metabolites. The half-life is from 1 to 4 hours.

Indications for use
The drug is used to eliminate pain in various locations, including toothache and pain during teething.
In addition, the drug is used to reduce elevated body temperature during childhood infections (including chicken pox, whooping cough, measles, mumps), ARVI and influenza. The drug can be used to treat post-vaccination hyperthermia in children.

Mode of application
Suspension for oral use containing 120 mg of active substance per 5 ml:
The drug is taken orally; it is recommended to dose the suspension using a special dosing device; it is not recommended to dissolve the suspension in water or tea, however, after administration, the suspension can be washed down with water or tea. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.
The recommended single dose of the drug is 10-15 mg/kg body weight, the daily dose is 60 mg/kg body weight. The interval between doses of the drug should be at least 4 hours. If you need to use the drug for more than 3 days in a row, you must contact your doctor.
For the treatment of post-vaccination hyperthermia, children aged 2-3 months are usually prescribed 2.5 ml of suspension. If necessary, a repeat dose of the drug is prescribed, but not earlier than 4 hours after the previous dose. If your body temperature has not returned to normal, you should consult your doctor.

Children aged 3 to 6 months are usually prescribed 4 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Children aged 6 months to 1 year are usually prescribed 5 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Children aged 1 to 2 years are usually prescribed 7 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Children aged 2 to 3 years are usually prescribed 9 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Children aged 3 to 6 years are usually prescribed 10 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Children aged 6 to 9 years are usually prescribed 14 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Children aged 9 to 12 years are usually prescribed 20 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Suppositories containing 125 mg of active substance:
The drug is administered rectally. To achieve the maximum therapeutic effect, it is recommended to use the drug after defecation. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.
Children aged 3 months to 3 years are usually prescribed 1 suppository 3 times a day with an interval of at least 4 hours. If you need to use the drug for more than 3 days in a row, you should consult your doctor.

Side effects
The drug is usually well tolerated by patients, but in some cases the following side effects may develop:
From the gastrointestinal tract and liver: nausea, vomiting, pain in the epigastric region, increased activity of liver enzymes, liver dysfunction. In addition, some laxative effects of the drug are possible.
From the hematopoietic system: anemia, including hemolytic anemia, sulfhemoglobinemia and methemoglobinemia.
Allergic reactions: skin rash, itching, urticaria, Stevens-Johnson syndrome, Lyell's syndrome, Quincke's edema, anaphylactic shock.
Others: bronchospasm (mainly in patients with hypersensitivity to nonsteroidal anti-inflammatory drugs), decreased blood sugar, including hypoglycemic coma.

Contraindications
Increased individual sensitivity to the components of the drug.
Children's age is less than 2 months.
The drug is not prescribed to patients with congenital hyperbilirubinemia, glucose-6-phosphate dehydrogenase deficiency and blood diseases, including anemia and leukopenia.
The drug should not be used to treat patients suffering from severe impairment of liver and/or kidney function.
The drug in the form of a suspension is contraindicated in patients with hereditary fructose intolerance.
The drug should be prescribed with caution to children aged 2-3 months who were born prematurely.

Drug interactions
When used simultaneously, metoclopramide and domperidone increase the absorption of paracetamol.
When combined with cholestyramine, a decrease in the absorption of paracetamol is observed.
With regular combined use of the drug with coumarin anticoagulants, including warfarin, the risk of bleeding may increase.
When used simultaneously, barbiturates reduce the antipyretic effect of paracetamol.
Inducers of microsomal liver enzymes, isoniazid and medicines, which have a hepatotoxic effect, enhance the hepatotoxic effect of paracetamol.
When used simultaneously, the drug reduces the effectiveness of diuretics.
Paracetamol is not used simultaneously with ethyl alcohol.

Overdose
With long-term use of high doses of the drug, disorders of the hematopoietic system may develop, including thrombocytopenia, pancytopenia, neutropenia, leukopenia, agranulocytosis and aplastic anemia. In addition, when using excessive doses of the drug, the development of interstitial nephritis, papillary necrosis, pallor of the skin, loss of appetite, nausea, abdominal pain and liver disorders is possible. In some cases, with an overdose of the drug, the development of drowsiness, psychomotor agitation, arrhythmia, tremors of the limbs and convulsions was noted. In case of severe poisoning with the drug, disorders of carbohydrate metabolism and metabolic acidosis may develop.
In case of overdose, gastric lavage, intake of enterosorbents and symptomatic therapy are indicated. If less than 48 hours have passed since taking the drug, oral methionine and intravenous administration of N-acetylcysteine are indicated. Overdose should be treated in a hospital setting.

Release form
Suspension of 100 ml in dark glass bottles, 1 bottle complete with a dosing device in a cardboard package.
Suppositories, 5 pieces in strips, 2 strips in a cardboard package.

Storage conditions
It is recommended to store the drug in a dry place away from direct sunlight at a temperature not exceeding 25 degrees Celsius.
The shelf life of the drug in the form of a suspension for oral use is 3 years.
The shelf life of the drug in the form of suppositories is 5 years.

Compound
5ml oral suspension contains:
Paracetamol – 120 mg;
Excipients, including sorbitol.

1 suppository contains:
Paracetamol – 125 mg;
Excipients.

Attention!
Description of the drug " Panadol Baby"on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

N02BE01 Paracetamol

Pharmacological group

Anilides

Composition and release form

5 ml of oral suspension contains paracetamol 120 mg; in bottles equipped with a plastic measuring spoon and a special protective cap, 100 and 300 ml, 1 set in a box. 1 rectal suppository - 125 mg; in polymer film 5 pcs., in cardboard box 2 films.

pharmachologic effect

Pharmacological effects - analgesic, antipyretic.

Suppresses the synthesis of PG in the central nervous system, reduces the excitability of the thermoregulation center in the hypothalamus, and increases heat transfer.

Pharmacodynamics

It has analgesic and antipyretic properties, the latter manifesting itself in febrile syndrome of any origin.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract. Plasma concentrations reach peak after 30-60 minutes; T1/2 plasma - 1-4 hours after taking therapeutic doses. Evenly distributed in the body. Metabolized in the liver to form paracetamol esters with glucuronic and sulfuric acids. 90-100% of the drug is excreted in the urine during the first day in the form of metabolites.

Indications for the drug Children's Panadol

Pain and fever syndromes (colds, flu, children's infectious diseases, toothache, pain during teething, ear pain with otitis media, headache, a sore throat).

Contraindications

Hypersensitivity.

Side effects

Erythematous and urticarial skin rash.

Interaction

T1/2 is prolonged by barbiturates and tricyclic antidepressants. The result is reduced by anticonvulsants.

Directions for use and doses

Suspension: orally, children from 3 months to 1 year are prescribed 1/2-1 measuring spoon (5 ml), children from 1 year to 6 years - 1-2 measuring spoons (5-10 ml), from 6 to 12 years - 2 -4 measuring spoons (10-20 ml). If necessary, re-prescribe every 4 hours (however, no more than 4 doses per day). Suppositories: rectally, children from 3 months to 3 years - 1 supp. every 4-6 hours (however, no more than 3 times a day).

Overdose

In the first 24 hours: pallor, nausea, vomiting, anorexia, pain in the abdominal area. After 12-48 hours: liver damage, metabolic disorders, metabolic acidosis. In severe poisoning, liver failure may progress (with the development of encephalopathy, coma and death). Acute renal failure with acute tubular necrosis can develop in isolation (in the absence of severe liver damage). Other disorders include cardiac arrhythmias and pancreatitis. Drug therapy: methionine orally or intravenously N-acetylcysteine (in the first 2 days after an overdose).

Precautionary measures

Do not use with other paracetamol-containing products. Prescribed with caution to children with impaired liver and kidney function. Before use in premature babies and children under 3 months (when taken for more than 3 days in a row), you should consult a doctor for advice.